Typical Properties
Physical and Chemical Properties
-
Freely soluble in water and a variety of organic solvents.
-
Free-flowing, Hygroscopic powder, solubilization, physiological compatibility, highly adhesive.
Chemical Description:
Product name: Povidone K
CAS NO.:9003-39-8
INCI Name: Polyvinylpyrrolidone (abbr. PVP)
APPLICATION
Provide rapid disintegration in a wide range of oral solid dosage formulations and processes. Especially in the following areas:
- Provide rapid disintegration in wide range of oral solid dosage formulations and processes.
- The optimum binder for solid preparations, suitable for wet granulation, dry granulation, direct compression and fluidized bed granulation.
- For quick release and anhydrous preparations drugs with poor water solubility, water sensitivity and poor compressibility.
- Improves compressibility, adhesion and hardness in tablets.
Improves dissolution and drug release. - Used as coating agent of active pharmaceutical ingredient enhance drug stability.
- Used as suspension stabilizer, increases the suspension stability or oral liquid preparations.
- Used as solubilizer to increase the solubility and bioavailability of insoluble drug preparation.
PACKING AND STORAGE
- Povidone K complies to USP-NF/Ph Eur./IP/BP.
- Packed in 25 kg or 50 kg fibre or plastic drum, inner lined with double polyethylene bag.
- Store in dry place at room temperature.
SPECIFICATION
|
NAME |
K-VALUE |
MOLECULAR WEIGHT |
IMPURITY A (ppm) |
PEROXIDES (ppm) |
2-P(%) |
ELEMENTAL IMPURITY COMPLIANCE |
|
Povidone K15 |
12.8-17.3 |
4500-9700 |
< 10.0 |
< 400 |
≤3.0 |
ICH Q3D |
|
Povidone K17 |
15.3-18.4 |
7100-11000 |
< 10.0 |
< 400 |
≤3.0 |
ICH Q3D |
|
Povidone K25 |
22.5-26.8 |
19300 -31100 |
< 10.0 |
< 400 |
≤3.0 |
ICH Q3D |
|
Povidone K30 |
27.0-32.1 |
31700-51400 |
< 10.0 |
< 400 |
≤3.0 |
ICH Q3D |
|
Povidone K90 |
81.0-96.3 |
790000-1350000 |
< 10.0 |
< 400 |
≤3.0 |
ICH Q3D |